Isixa esikhulu se-buffers sifuneka kwinkqubo yokucoca ezantsi kwe-biophaphamam ye-biophapharmaceuticals. Ukuchaneka kunye nokuzala kwee-buffers kunefuthe elikhulu kwinkqubo yokucoca iprotein. Inkqubo ye-intanethi ye-intanethi kunye ne-intanethi ye-intanethi inokudibanisa iintlobo ezahlukeneyo zezinto ezithengiswayo. Utywala bukamama kunye ne-rindent ixutywe kwi-intanethi ukufumana isisombululo ekujolise kulo. Imveliso isekwe kulwazi lwenzululwazi, kwaye umgangatho uvela kwingcinga yoyilo (i-QBD). Ngalo lonke ixesha lokwenyani Inkqubo yokulungiselela inkcubeko ifuna inani elikhulu leetanki kunye nevolumu enkulu. I-Iven izisa abathengi amava obuchwephesha amatsha, ukunciphisa inyawo le-Buffer Dosing kwindawo yokucoca, kunye nokunciphisa iindleko zotyalo-mali ngaphambi kwemveliso kunye neendleko zokusebenza kunye nokusebenza. , Ukuphucula ukusebenza kwemveliso, qinisekisa ukuba iiparamitha ezibalulekileyo (CPP) ze-buffer kunye nokulandelwa kwayo, kwaye ekugqibeleni ekugqibeleni ziphucule umgangatho.