Ukuhlanjululwa kwi-Intanethi kunye nezixhobo zokudosa kwi-intanethi
Ingcaciso yeMveliso:
Isixa esikhulu se-buffers siyafuneka kwinkqubo yokucoca ezantsi kwe-biopharmaceuticals.Ukuchaneka kunye nokuveliswa kwakhona kwee-buffers kunempembelelo enkulu kwinkqubo yokucoca iprotheni.I-intanethi ye-dilution kunye nenkqubo yokudosa kwi-intanethi inokudibanisa iintlobo ngeentlobo ze-buffers zecandelo elinye.Utywala lukamama kunye ne-diluent zidityaniswe kwi-intanethi ukufumana isisombululo esijoliswe kuyo.Imveliso isekelwe kulwazi lwesayensi, kwaye umgangatho uvela kwingcamango yoyilo (QbD).Ngokusebenzisa ixesha langempela kwi-intanethi (i-Real in time) ukubeka iliso kunye nokulawulwa kwezikhombisi ezimbini zeekhemikhali, iimpawu eziphambili zekhwalithi (CQA) zemveliso (CQA), i-pH kunye ne-conductivity ngexesha lenkqubo yokuvelisa, Ukuqinisekisa ukubonelela ngee-buffers ezizinzileyo kunye neyunifomu. umgangatho weenkqubo ezisezantsi zokunceda iinjongo zokukhutshwa kweparamitha yeenkampani zebiopharmaceutical.Inkqubo yokulungiselela ulwelo lwemveli ifuna inani elikhulu lamatanki kunye nomthamo omkhulu.I-VEN izisa abathengi amava amatsha obugcisa, ukunciphisa unyawo lwe-buffer dosing kwinqanaba lenkqubo yokucoca, kunye nokunciphisa utyalo-mali lwangaphambili kunye neendleko zasemva kokuveliswa kunye nokusebenza., Ukuphucula ukusebenza kakuhle kwemveliso, qinisekisa iiparameters zenkqubo ebalulekileyo (CPP) ye-buffer kunye nokulandeleka kwayo, kwaye ekugqibeleni uphucule umgangatho wamayeza.