Kwimimandla ye-biotechnology kunye ne-biopharmaceutical, amagama athi "bioreactor" kunye ne "biofermenter" ahlala esetyenziswa ngokutshintshana, kodwa abhekisela kwiinkqubo ezahlukeneyo ezinemisebenzi ethile kunye nezicelo. Ukuqonda umahluko phakathi kwezi ntlobo zimbini zezixhobo kubalulekile kwiingcali kwintsimi, ngakumbi xa kuyilwa kunye neenkqubo zokuvelisa ezihlangabezana nemigangatho engqongqo yolawulo.

Ukuchaza imigaqo

I-Bioreactor ligama elibanzi eliquka nasiphi na isikhongozeli apho i-biological reaction yenzeke. Oku kunokubandakanya iinkqubo ezahlukeneyo njengokubilisa, inkcubeko yeeseli, kunye nokusabela kwe-enzyme. I-Bioreactors inokuthi iyilelwe iimeko ze-aerobic okanye i-anaerobic kwaye inokuxhasa uluhlu olubanzi lwezinto eziphilayo, kubandakanya ibhaktheriya, igwele, kunye neeseli ezincancisayo. Baxhotyiswe ngeentlobo ezahlukeneyo zamaqondo obushushu, i-pH, inqanaba le-oksijini, kunye nolawulo lokuphazamiseka ukuze kunyuswe iimeko zokukhula kwee-microorganisms ezikhuliswe okanye iiseli.

I-biofermenter, ngakolunye uhlangothi, luhlobo oluthile lwe-bioreactor olusetyenziswa ngokukodwa kwiinkqubo zokuvutshelwa. Ukuvubela yinkqubo yemetabolism esebenzisa i-microorganisms, igwele okanye ibhaktheriya, ukuguqula iswekile ibe ziiasidi, iigesi, okanye utywala.Biofermenters ziyilelwe ukudala indawo ehambelana nokukhula kwezi microorganisms, ngaloo ndlela ivelisa iindidi ze-bioproducts ezifana ne-ethanol, i-organic acids, kunye namayeza.

Iiyantlukwano eziphambili

Umsebenzi:

I-Bioreactors ingasetyenziselwa iintlobo ezahlukeneyo ze-bioprocesses, kubandakanywa inkcubeko yeseli kunye neempendulo ze-enzyme, ngelixa i-fermenters yenzelwe ngokukodwa iinkqubo zokuvutshelwa.

IiNgcaciso zoyilo:
Biofermenterszidla ngokuyilwa ngeempawu ezithile ukuhlangabezana neemfuno zezinto eziphilayo ezibilayo. Ngokomzekelo, banokubandakanya iimpawu ezifana ne-baffles ukuphucula ukuxuba, iinkqubo ezithile ze-aeration ze-aerobic fermentation, kunye neenkqubo zokulawula ubushushu ukugcina iimeko zokukhula ezifanelekileyo.

Isicelo:
Ii-Bioreactors ziguquguquka kakhulu kwaye zinokusetyenziswa kwizicelo ezahlukeneyo kumashishini ahlukeneyo, kubandakanya amayeza, ukutya kunye neziselo, kunye ne-biotechnology yokusingqongileyo. Ngokwahlukileyo koko, izibilisi zisetyenziswa ikakhulu kwimizi-mveliso evelisa iimveliso zokuvutshelwa, njengokwenza iwayini, ukwenziwa kwebhiya nemveliso yebiofuel.

Isikali:
Zombini ii-bioreactors kunye ne-fermenters zinokuyilwa ukuya kwizikali ezahlukeneyo, ukusuka kuphando lwebhubhoratri ukuya kwimveliso yeshishini. Nangona kunjalo, izibilisi zihlala zinesakhono esikhulu sokuthwala izixa ezikhulu zemveliso eqhele ukwenziwa ngexesha lenkqubo yokuvubela.

Indima ye-GMP kunye ne-ASME-BPE kuyilo lwe-fermenter

Ukuthotyelwa kwemigangatho yolawulo kubalulekile xa kuziwa kuyilo kunye nokwenziwabio-fermenters. Kwi-VEN, siqinisekisa ukuba i-fermenters yethu iyilwe kwaye yenziwe ngokuthobela ngokungqongqo i-Good Manufacturing Practice (GMP) imigaqo kunye ne-ASME-BPE (i-American Society of Mechanical Engineers - i-Bioprocessing Equipment) iimfuno. Oku kuzibophelela kumgangatho kunye nokhuseleko kubalulekile kubathengi bethu be-biopharmaceutical abaxhomekeke kwizixhobo zethu zokuvubela inkcubeko ye-microbial.

Yethuiitanki zokubilisaibonakalisa ubuchwephesha, ubuchwephesha obusebenzisekayo kunye noyilo lwemodyuli olunokuthi ludityaniswe lula kwiinkqubo ezikhoyo. Sinikezela ngemikhumbi ehambelana nemigangatho eyahlukeneyo yenqanawa yoxinzelelo lwelizwe, kuquka i-ASME-U, i-GB150 kunye ne-PED (i-Pressure Equipment Directive). Oku kuguquguquka kuqinisekisa ukuba iitanki zethu zinokuthatha uluhlu olubanzi lwezicelo kunye neemfuno zokulawula.

Ukwenza ngokwezifiso kunye noKuguquguquka

Kwi-VEN, siyaqonda ukuba umthengi ngamnye we-biopharmaceutical uneemfuno ezizodwa. Yiyo loo nto sinikezela ngoluhlu olupheleleyo lwezibilisi zokulima iintsholongwane, ukusuka kwilabhoratri ye-R&D ukuya kulingo kunye nemveliso yeshishini. Ama-fermenters ethu angenziwa ngokwezifiso kwiimfuno ezithile, kubandakanywa umthamo, ukusuka kwiilitha ezi-5 ukuya kwii-kilolitha ezingama-30. Oku kuguquguquka kusivumela ukuba sihlangabezane neemfuno zebhaktheriya ene-aerobic kakhulu, njenge-Escherichia coli kunye ne-Pichia pastoris, esetyenziswa ngokuqhelekileyo kwimveliso ye-biopharmaceutical.

Isishwankathelo, ngelixa zombini i-bioreactors kunyebiofermenterszidlala indima ebalulekileyo kwinkalo ye-biotechnology, zisetyenziselwa iinjongo ezahlukeneyo kwaye ziyilwe zinemisebenzi eyahlukeneyo engqondweni. Ukuqonda lo mahluko kubalulekile ekukhetheni izixhobo ezifanelekileyo kwisicelo esithile. Kwi-VENN, sizimisele ukubonelela ngezivundisi ezikumgangatho ophezulu ezihlangabezana neemfuno ezingqongqo zeshishini le-biopharmaceutical, ukuqinisekisa ukuba abathengi bethu banokufikelela ezona ziphumo zibalaseleyo kwiinkqubo zabo zokulima i-microbial. Nokuba ukumanqanaba okuqala ophando okanye ukonyusa imveliso yemizi-mveliso, ubuchule bethu kunye nezisombululo ezinokwenziwa ngokwezifiso zinokukunceda ngokuzithemba ujonge ubunzima be-bioprocessing.