Kwimida ye-biotechnology kunye ne-biopharmaceutical, amagama athi "bioreactor" kunye nelithi "biofermenter" adla ngokusetyenziswa ngokutshintshana, kodwa abhekisa kwiinkqubo ezahlukeneyo ezinemisebenzi ethile kunye nokusetyenziswa. Ukuqonda umahluko phakathi kwezi ntlobo zimbini zezixhobo kubalulekile kwiingcali kweli candelo, ingakumbi xa kuyilwa kwaye kuveliswa iinkqubo ezihlangabezana nemigangatho engqongqo yokulawula.

Amagama achazayo

I-Bioreactor ligama elibanzi eligubungela nasiphi na isikhongozeli apho kwenzeka khona ukusabela kwezinto eziphilayo. Oku kungabandakanya iinkqubo ezahlukeneyo njengokubilisa, inkcubeko yeeseli, kunye nokusabela kwee-enzyme. Ii-Bioreactors zinokuyilwa kwiimeko ze-aerobic okanye ze-anaerobic kwaye zinokuxhasa uluhlu olubanzi lwezinto eziphilayo, kubandakanya iibhaktheriya, igwele, kunye neeseli zezilwanyana ezincancisayo. Zixhotyiswe ngamaqondo obushushu ahlukeneyo, i-pH, inqanaba leoksijini, kunye nolawulo lokushukuma ukuze kuphuculwe iimeko zokukhula kweentsholongwane okanye iiseli ezikhuliswe.

Kwelinye icala, i-biofermenter luhlobo oluthile lwe-bioreactor olusetyenziswa kakhulu kwiinkqubo zokubilisa. Ukubilisa yinkqubo ye-metabolism esebenzisa iintsholongwane, ezidla ngokuba yi-yeast okanye iibhaktheriya, ukuguqula iiswekile zibe zii-asidi, iigesi, okanye utywala.Ii-Biofermenters zenzelwe ukudala imeko-bume ekhuthaza ukukhula kwezi microorganisms, ngaloo ndlela zivelisa iintlobo ngeentlobo zeemveliso zebhayoloji ezifana ne-ethanol, ii-organic acids, kunye namayeza.

Umahluko oPhambili

Umsebenzi:

Ii-bioreactors zingasetyenziselwa iintlobo ngeentlobo ze-bioprocesses, kuquka inkcubeko yeseli kunye neempendulo ze-enzyme, ngelixa ii-fermenters zenzelwe ngokukodwa iinkqubo zokubilisa.

Iinkcukacha zoYilo:
Ii-BiofermentersZidla ngokuyilwa ngeempawu ezithile ukuhlangabezana neemfuno zezinto eziphilayo ezibilayo. Umzekelo, zinokubandakanya iimpawu ezifana nee-baffles zokuphucula ukuxubana, iinkqubo ezithile zokungenisa umoya ukuze kubiliswe i-aerobic, kunye neenkqubo zokulawula ubushushu ukuze kugcinwe iimeko zokukhula ezifanelekileyo.

Isicelo:
Ii-bioreactors zisebenziseka ngeendlela ezahlukeneyo kwaye zingasetyenziselwa usetyenziso olwahlukeneyo kumashishini ahlukeneyo, kubandakanya amayeza, ukutya neziselo, kunye ne-biotechnology yokusingqongileyo. Ngokwahlukileyo koko, ii-fermenters zisetyenziswa kakhulu kumashishini avelisa iimveliso zokubilisa, njengokwenza iwayini, ukupheka, kunye nokuvelisa i-biofuel.

Isikali:
Zombini ii-bioreactors kunye nee-fermenters zinokuyilwa ngokwezikali ezahlukeneyo, ukusuka kuphando lwelabhoratri ukuya kwimveliso yemizi-mveliso. Nangona kunjalo, ii-fermenters zihlala zinamandla amakhulu okwamkela inani elikhulu lemveliso eveliswa ngexesha lenkqubo yokubilisa.

Indima ye-GMP kunye ne-ASME-BPE kuyilo lwe-fermenter

Ukuthobela imigangatho yolawulo kubalulekile xa kufikwa kuyilo kunye nokwenziwa kweii-bio-fermentersApha e-IVEN, siqinisekisa ukuba izixhobo zethu zokuvundisa ziyilwe kwaye zenziwe ngokuhambelana nemigaqo yeGood Manufacturing Practice (GMP) kunye neemfuno ze-ASME-BPE (American Society of Mechanical Engineers - Bioprocessing Equipment). Oku kuzibophelela kumgangatho nokhuseleko kubalulekile kubathengi bethu be-biopharmaceutical abaxhomekeke kwizixhobo zethu zokuvundisa inkcubeko yeentsholongwane.

Zethuiitanki zokubilisaibonisa uyilo lobuchwephesha, olusebenziseka lula nolunemodyuli olunokufakwa ngokulula kwiinkqubo ezikhoyo. Sinikezela ngeenqanawa ezihambelana nemigangatho eyahlukeneyo yesizwe yeenqanawa zoxinzelelo, kubandakanya i-ASME-U, i-GB150 kunye ne-PED (Pressure Equipment Directive). Olu tshintsho luqinisekisa ukuba iitanki zethu zinokuhlangabezana noluhlu olubanzi lwezicelo kunye neemfuno zomthetho.

Ukwenza ngokwezifiso kunye nokuguquguquka

Apha kwi-IVEN, siyaqonda ukuba umthengi ngamnye we-biopharmaceutical uneemfuno ezizodwa. Yiyo loo nto sinikezela uluhlu olupheleleyo lwee-fermenters zokulima iintsholongwane, ukusuka kwi-R&D yelebhu ukuya kwimveliso yovavanyo kunye neyemizi-mveliso. Ii-fermenters zethu zinokwenziwa ngokwezifiso ngokweemfuno ezithile, kubandakanya umthamo, ukusuka kwiilitha ezi-5 ukuya kwiikhilolitha ezingama-30. Olu kuguquguquka lusenza sikwazi ukuhlangabezana neemfuno zeebhaktheriya ezinamandla kakhulu, ezifana ne-Escherichia coli kunye ne-Pichia pastoris, ezisetyenziswa kakhulu kwimveliso ye-biopharmaceutical.

Ngamafutshane, ngelixa zombini ii-bioreactors kunyeii-biofermentersZidlala indima ebalulekileyo kwicandelo le-biotechnology, zisetyenziselwa iinjongo ezahlukeneyo kwaye ziyilwe ngemisebenzi eyahlukeneyo engqondweni. Ukuqonda la mahluko kubalulekile ekukhetheni izixhobo ezifanelekileyo zesicelo esithile. Kwi-IVEN, sizimisele ukubonelela ngee-fermenters ezikumgangatho ophezulu ezihlangabezana neemfuno ezingqongqo zoshishino lwe-biopharmaceutical, ukuqinisekisa ukuba abathengi bethu banokufikelela kwiziphumo ezilungileyo kwiinkqubo zabo zokulima iintsholongwane. Nokuba ukwinqanaba lokuqala lophando okanye ukwandisa imveliso yemizi-mveliso, ubuchule bethu kunye nezisombululo ezinokwenziwa ngokwezifiso zinokukunceda uhambe ngokuzithemba kwiingxaki ze-bioprocessing.